Annals of Vascular Surgery
Volume 21, Issue 1 , Pages 61-66 , January 2007

Cyclooxygenase-2 Expression and Its Association with Increased Angiogenesis in Human Abdominal Aortic Aneurysms

  • K.S. Chapple, FRCS

      Affiliations

    • Academic Unit of Vascular Surgery, University of Leeds, St. James's University Hospital, Leeds, UK
    • Corresponding Author InformationCorrespondence to: K.S. Chapple, FRCS, Department of Colorectal Surgery, The Alfred Hospital, Commercial Road, Melbourne, Vic 3004, Australia
    • ,
  • D.J. Parry, FRCS

      Affiliations

    • Academic Unit of Vascular Surgery, University of Leeds, St. James's University Hospital, Leeds, UK
    • ,
  • S. McKenzie, MRCS

      Affiliations

    • Academic Unit of Vascular Surgery, University of Leeds, St. James's University Hospital, Leeds, UK
    • ,
  • K.A. MacLennan, MRCPath

      Affiliations

    • Department of Histopathology, University of Leeds, St. James's University Hospital, Leeds, UK
    • ,
  • P. Jones, PhD

      Affiliations

    • Molecular Medicine Unit, University of Leeds, St. James's University Hospital, Leeds, UK
    • ,
  • D.J.A. Scott, FRCS

      Affiliations

    • Academic Unit of Vascular Surgery, University of Leeds, St. James's University Hospital, Leeds, UK

References 

  1. Ashton HA, Buxton MJ, Day NE, et al. The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial. Lancet. 2002;360:1531–1539
  2. Freestone T, Turner RJ, Coady A, et al. Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol. 1995;15:1145–1151
  3. Holmes DR, Petrinec D, Wester W, et al. Indomethacin prevents elastase-induced abdominal aortic aneurysms in the rat. J Surg Res. 1996;63:305–309
  4. Miralles M, Wester W, Sicard GA, et al. Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the COX2 isoform of cyclooxygenase. J Vasc Surg. 1999;29:884–893
  5. Herschman HR. Prostaglandin synthase 2. Biochim Biophys Acta. 1996;1299:125–140
  6. Hong BK, Kwon HM, Lee BK, et al. Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions. Yonsei Med J. 2000;41:82–88
  7. Holmes DR, Wester W, Thompson RW, et al. Prostaglandin E2 synthesis and cyclooxygenase expression in abdominal aortic aneurysms. J Vasc Surg. 1997;25:810–815
  8. Walton LJ, Franklin IJ, Bayston T, et al. Inhibition of prostaglandin E2 synthesis in abdominal aortic aneurysms. Circulation. 1999;100:48–54
  9. Franklin IJ, Walton LJ, Greenhalgh RM, et al. The influence of indomethacin on the metabolism and cytokine secretion of human aneurysmal aorta. Eur J Vasc Endovasc Surg. 1999;18:35–42
  10. Pentland AP, Shapiro SD, Welgus HG. Agonist-induced expression of tissue inhibitor of metalloproteinases and metalloproteinases by human macrophages is regulated by endogenous prostaglandin E2 synthesis. J Invest Dermatol. 1995;104:52–57
  11. Hinson RM, Williams JA, Shacter E. Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: possible role of cyclooxygenase-2. Proc Natl Acad Sci USA. 1996;93:4885–4890
  12. Bayston T, Ramessur S, Reise J, et al. Prostaglandin E2 receptors in abdominal aortic aneurysm and human aortic smooth muscle cells. J Vasc Surg. 2003;38:354–359
  13. Chapple KS, Cartwright EJ, Hawcroft G, et al. Localization of cyclooxygenase-2 in human sporadic colorectal adenomas. Am J Pathol. 2000;156:545–553
  14. Chinery R, Beauchamp RD, Shyr Y, et al. Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells. Cancer Res. 1998;58:2323–2327
  15. DeWitt DL, Meade EA. Serum and glucocorticoid regulation of gene transcription and expression of the prostaglandin H synthase-1 and prostaglandin H synthase-2 isozymes. Arch Biochem Biophys. 1993;306:94–102
  16. Xu X-M, Sansores-Garcia L, Chen X-M, et al. Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate. Proc Natl Acad Sci USA. 1999;96:5292–5297
  17. Jones DA, Carlton DP, McIntyre TM, et al. Molecular cloning of human endoperoxide synthase type II and demonstration of expression in response to cytokines. J Biol Chem. 1993;268:9049–9054
  18. Young W, Mahboubi K, Haider A, et al. Cyclooxygenase-2 is required for tumour necrosis factor-alpha- and angiotensin II-mediated proliferation of vascular smooth muscle cells. Circ Res. 2000;86:906–914
  19. Arias-Negrete S, Keller K, Chadee K. Proinflammatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophages. Biochem Biophys Res Commun. 1995;208:582–589
  20. Ailawadi G, Eliason JL, Upchurch GR. Current concepts in the pathogenesis of abdominal aortic aneurysm. J Vasc Surg. 2003;38:584–588
  21. Doroudi R, Gan LM, Selin Sjogren L, et al. Effects of shear stress on eicosanoid gene expression and metabolite production in vascular endothelium as studied in a novel biomechanical perfusion model. Biochem Biophys Res Commun. 2000;269:257–264
  22. Inoue H, Taba Y, Miwa Y, et al. Transcriptional and posttranscriptional regulation of cyclooxygenase-2 expression by fluid shear stress in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2002;22:1415–1420
  23. Yan Z, Subbaramaiah K, Camilli T, et al. Benzo[a]pyrene induces the transcription of cyclooxygenase-2 in vascular smooth muscle cells. J Biol Chem. 2000;275:4949–4955
  24. Kazi M, Thyberg J, Religa P, et al. Influence of intraluminal thrombus on structural and cellular composition of abdominal aortic aneurysm wall. J Vasc Surg. 2003;38:1283–1292
  25. Vorp DA, Lee PC, Wang DH, et al. Association between intraluminal thrombus in abdominal aortic aneurysm with local hypoxia and wall weakening. J Vasc Surg. 2001;34:291–299
  26. Ji YS, Xu Q, Schmedtje JF. Hypoxia induces high-mobility-group protein I(Y) and transcription of the cyclooxygenase-2 gene in human vascular endothelium. Circ Res. 1998;83:295–304
  27. Kobayashi M, Matsubara J, Matsushita M, et al. Expression of angiogenesis and angiogenic factors in human aortic vascular disease. J Surg Res. 2002;106:239–245
  28. Holmes DR, Liao S, Parks WC, et al. Medial neovascularization in abdominal aortic aneurysms; a histopathologic marker of aneurysmal degeneration with pathophysiologic implications. J Vasc Surg. 1995;21:761–771
  29. Schneiderman J, Bordin GM, Engelberg I, et al. Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. J Clin Invest. 1995;96:639–645
  30. Thompson MM, Jones L, Nasim A, et al. Angiogenesis in abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 1996;11:464–469
  31. Satta J, Soini Y, Mosorin M, et al. Angiogenesis is associated with mononuclear inflammatory cells in abdominal aortic aneurysms. Ann Chir Gynaecol. 1998;87:40–42
  32. Bernardini G, Ribatti D, Spinetti G, et al. Analysis of the role of chemokines in angiogenesis. J Immunol Methods. 2003;273:83–101
  33. Tsujii M, Kawano S, Tsuji S, et al. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell. 1998;93:705–716
  34. Hull MA, Thomson JL, Hawkey CJ. Expression of cyclooxygenase 1 and 2 by human gastric endothelial cells. Gut. 1999;45:529–536
  35. Kuwano T, Nakao S, Yamamoto H, et al. Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis. FASEB J. 2004;18:300–310
  36. Sawaoka H, Tsuji S, Tsujii M, et al. Cyclooxygenase inhibitors suppress angiogenesis and reduce tumor growth in vivo. Lab Invest. 1999;79:1469–1477
  37. Masferrer JL, Leahy KM, Koki AT, et al. Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. Cancer Res. 2000;60:1306–1311

PII: S0890-5096(06)00016-1

doi: 10.1016/j.avsg.2006.10.008

Annals of Vascular Surgery
Volume 21, Issue 1 , Pages 61-66 , January 2007

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