Annals of Vascular Surgery
Volume 20, Issue 2 , Pages 228-236 , March 2006

Localized Administration of Doxycycline Suppresses Aortic Dilatation in an Experimental Mouse Model of Abdominal Aortic Aneurysm

  • Michel A. Bartoli, MD

      Affiliations

    • Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO, USA
    • Department of Vascular Surgery, Hôpital La Timone, Marseille, France
    • ,
  • Federico E. Parodi, MD

      Affiliations

    • Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO, USA
    • ,
  • Jack Chu, PhD

      Affiliations

    • Medtronic AVE, Santa Rosa, CA, USA
    • ,
  • Monica B. Pagano, MD

      Affiliations

    • Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO, USA
    • ,
  • Dongli Mao, MD

      Affiliations

    • Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO, USA
    • ,
  • B. Timothy Baxter, MD

      Affiliations

    • Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
    • ,
  • Celine Buckley, MD

      Affiliations

    • Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO, USA
    • ,
  • Terri L. Ennis, BS

      Affiliations

    • Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO, USA
    • ,
  • Robert W. Thompson, MD

      Affiliations

    • Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO, USA
    • Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA
    • Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA
    • Corresponding Author InformationCorrespondence to: Robert W. Thompson, MD, Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, 5101 Queeny Tower, One Barnes-Jewish Hospital Plaza, St. Louis, MO 63110, USA

REFERENCES 

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  2. Lederle FA , Wilson SE , Johnson GR , et al.   Immediate repair compared with surveillance of small abdominal aortic aneurysms . N Engl J Med . 2002;346:1437–1444
  3. Powell JT , Brady AR . Detection, management, and prospects for the medical treatment of small abdominal aortic aneurysms . Arterioscler Thromb Vasc Biol . 2004;24:241–245
  4. Koch AE , Haines GK , Rizzo RJ , et al.   Human abdominal aortic aneurysms. Immunophenotypic analysis suggesting an immune-mediated response . Am J Pathol . 1990;137:1199–1213
  5. Freestone T , Turner RJ , Coady A , Higman DJ , Greenhalgh RM , Powell JT . Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm . Arterioscler Thromb Vasc Biol . 1995;15:1145–1151
  6. Pyo R , Lee JK , Shipley JM , et al.   Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms . J Clin Invest . 2000;105:1641–1649
  7. Longo GM , Xiong W , Greiner TC , Zhao Y , Fiotti N , Baxter BT . Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms . J Clin Invest . 2002;110:625–632
  8. Thompson RW , Baxter BT . MMP inhibition in abdominal aortic aneurysms: rationale for a prospective randomized clinical trial . Ann NY Acad Sci . 1999;878:159–178
  9. Golub LM , Lee HM , Ryan ME , Giannobile WV , Payne J , Sorsa T . Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms . Adv Dent Res . 1998;12:12–26
  10. Petrinec D , Liao S , Holmes DR , Reilly JM , Parks WC , Thompson RW . Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase . J Vasc Surg . 1996;23:336–346
  11. Prall AK , Longo GM , Mayhan WG , et al.   Doxycycline in patients with abdominal aortic aneurysms and in mice: comparison of serum levels and effect on aneurysm growth in mice . J Vasc Surg . 2002;35:923–929
  12. Kaito K , Urayama H , Watanabe G . Doxycycline treatment in a model of early abdominal aortic aneurysm . Surg Today . 2003;33:426–433
  13. Manning MW , Cassis LA , Daugherty A . Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms . Arterioscler. Thromb Vasc Biol . 2003;23:483–488
  14. Curci JA , Mao D , Bohner DG , et al.   Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms . J Vasc Surg . 2000;31:325–342
  15. Baxter BT , Pearce WH , Waltke EA , et al.   Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (phase II) multicenter study . J Vasc Surg . 2002;36:1–12
  16. Mosorin M , Juvonen J , Biancari F , et al.   Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study . J Vasc Surg . 2001;34:606–610
  17. Steinmetz EF , Buckley C , Shames ML , et al.   Treatment with simvastatin suppresses the development of experimental abdominal aortic aneurysms in normal and hypercholesterolemic mice . Ann Surg . 2005;241:92–101
  18. Sho E , Chu J , Sho M , et al.   Continuous periaortic infusion improves doxycycline efficacy in experimental aortic aneurysms . J Vasc Surg . 2004;39:1312–1321
  19. Franklin IJ , Harley SL , Greenhalgh RM , Powell JT . Uptake of tetracycline by aortic aneurysm wall and its effect on inflammation and proteolysis . Br J Surg . 1999;86:771–775

 Portions of this work were initially presented at the Lifeline Foundation Research Forum of the Society for Vacular Surgery, June 3–6, 2004, Anaheim, CA.

PII: S0890-5096(06)60036-8

doi: 10.1007/s10016-006-9017-z

Annals of Vascular Surgery
Volume 20, Issue 2 , Pages 228-236 , March 2006

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