Annals of Vascular Surgery
Volume 20, Issue 2 , Pages 243-249 , March 2006

Effects of Cyclosporin A on Neurological Outcome and Serum Biomarkers in the Same Setting of Spinal Cord Ischemia Model

  • Erdem A. Ozkisacik, MD

      Affiliations

    • Department of Cardiovascular Surgery, Adnan Menderes University Medical Faculty, Aydin, Turkey
    • Corresponding Author InformationCorrespondence to: Erdem A. Ozkisacik, MD, Adnan Menderes University, Tip Fakultesi, Kalp ve Damar Cerrahisi Anabilim Dali, Aydin 09100, Turkey
  • ,
  • Berent Discigil, MD

      Affiliations

    • Department of Cardiovascular Surgery, Adnan Menderes University Medical Faculty, Aydin, Turkey
  • ,
  • Mehmet Boga, MD

      Affiliations

    • Department of Cardiovascular Surgery, Adnan Menderes University Medical Faculty, Aydin, Turkey
  • ,
  • Ugur Gurcun, MD

      Affiliations

    • Department of Cardiovascular Surgery, Adnan Menderes University Medical Faculty, Aydin, Turkey
  • ,
  • Muharrem I. Badak, MD

      Affiliations

    • Department of Cardiovascular Surgery, Adnan Menderes University Medical Faculty, Aydin, Turkey
  • ,
  • Tunay Kurtoglu, MD

      Affiliations

    • Department of Cardiovascular Surgery, Adnan Menderes University Medical Faculty, Aydin, Turkey
  • ,
  • Cigdem Yenisey, MD

      Affiliations

    • Department of Biochemistry, Adnan Menderes University Medical Faculty, Aydin, Turkey
  • ,
  • Emel Dikicioglu, MD

      Affiliations

    • Department of Pathology, Adnan Menderes University Medical Faculty, Aydin, Turkey

REFERENCES 

  1. Svensson LG , Crawford ES , Hess KR , et al.   Experience with 1509 patients undergoing thoracoabdominal aortic operations . J Vasc Surg . 1993;17:357–370
  2. Gharagozloo F , Larson J , Dausmann MJ , et al.   Spinal cord protection during surgical procedures on the descending thoracic and thoracoabdominal aorta: review of current techniques . Chest . 1996;109:799–809
  3. Qayumi AK , Janusz MT , Jamieson WR , et al.   Pharmacologic interventions for prevention of spinal cord injury caused by aortic crossclamping . J Thorac Cardiovasc Surg . 1992;104:256–261
  4. Wan IY , Angelini GD , Bryan AJ , et al.   Prevention of spinal cord ischaemia during descending thoracic and thoracoabdominal aortic surgery . Eur J Cardiothorac Surg . 2001;19:203–213
  5. Atzeni F , Sarzi-Puttini P , Capsoni F , et al.   Successful treatment of pure red cell aplasia in systemic lupus erythematosus with cyclosporin A . Clin Exp Rheumatol . 2003;21:759–762
  6. Morris PJ . Cyclosporine, FK-506 and other drugs in organ transplantation . Curr Opin Immunol . 1991;3:748–751
  7. Cheung A , Menkis AH . Cyclosporine heart transplantation . Transplant Proc . 1998;30:1881–1884
  8. Kaminska B , Gaweda-Walerych K , Zawadzka M . Molecular mechanisms of neuroprotective action of immunosuppressants - facts and hypotheses . J Cell Mol Med . 2004;8:45–58
  9. Navarro-Gonzalvez JA , Garcia-Benayas C , Arenas J . Semi-automated measurement of nitrate in biological fluids . Clin Chem . 1998;44:679–681
  10. Johnson SH , Kraimer JM , Graeber GM . Effects of flunarizine on neurological recovery and spinal cord blood flow in experimental spinal cord ischemia in rabbits . Stroke . 1993;24:1547–1553
  11. Almeida A , Delgado-Esteban M , Bolanos JP , et al.   Oxygen and glucose deprivation induces mitochondrial dysfunction and oxidative stress in neurones but not in astrocytes in primary culture . J Neurochem . 2002;81:207–217
  12. Hansson MJ , Persson T , Friberg H , et al.   Powerful cyclosporin inhibition of calcium-induced permeability transition in brain mitochondria . Brain Res . 2003;960:99–111
  13. Persson L , Hardemark HG , Gustafsson J , et al.   S-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous system . Stroke . 1987;18:911–918
  14. Cunningham RT , Young IS , Winder J , et al.   Serum neurone specific enolase (NSE) levels as an indicator of neuronal damage in patients with cerebral infarction . Eur J Clin Invest . 1991;21:497–500
  15. Loy DN , Sroufe AE , Pelt JL , et al.   Serum biomarkers for experimental acute spinal cord injury: rapid elevation of neuron-specific enolase and S-100beta . Neurosurgery . 2005;56:391–397
  16. Fischer S , Clauss M , Wiesnet M , et al.   Hypoxia induces permeability in brain microvessel endothelial cells via VEGF and NO . Am J Physiol . 1999;276:812–820
  17. Marchi N , Rasmussen P , Kapural M , et al.   Peripheral markers of brain damage and blood-brain barrier dysfunction . Restor Neurol Neurosci . 2003;21:109–121
  18. Sullivan PG , Rabchevsky AG , Hicks RR , et al.   Dose-response curve and optimal dosing regimen of cyclosporin A after traumatic brain injury in rats . Neuroscience . 2000;101:289–295
  19. Tachibana T , Shiiya N , Kunihara T , et al.   Immunophilin ligands FK506 and cyclosporine A improve neurologic and histopathologic outcome after transient spinal cord ischemia in rabbits . J Thorac Cardiovasc Surg . 2005;129:123–128
  20. Sato M , Horinouchi T , Sakurai M , et al.   Cyclosporin A reduces delayed motor neuron death after spinal cord ischemia in rabbits . Ann Thorac Surg . 2003;75:1294–1299
  21. Mobley LW , Agrawal SK . Role of calcineurin in calcium-mediated hypoxic injury to white matter . Spine J . 2003;3:11–18
  22. In JH , Lee JE , Lim YG , et al.   Regulation and localization of neuronal nitric oxide synthase in the ischemic rabbit spinal cord . Mol Cells . 2003;15:406–411
  23. Diaz-Ruiz A , Vergara P , Perez-Severiano F , et al.   Cyclosporin A inhibits constitutive nitric oxide synthase activity and neuronal and endothelial nitric oxide synthase expressions after spinal cord injury in rats . Neurochem Res . 2005;30:245–251

 This study was presented at the Fourth European Association for Cardio-thoracic Surgery/The European Society of Thoracic Surgeons Joint Meeting, Barcelona, Spain, September 24–28, 2005.

PII: S0890-5096(06)60038-1

doi: 10.1007/s10016-006-9022-2

Annals of Vascular Surgery
Volume 20, Issue 2 , Pages 243-249 , March 2006