Background
Aortoiliac occlusive disease (AOD) and abdominal aortic aneurysm (AAA) are very important
cardiovascular diseases that present different aspects of pathophysiology; however,
oxidative stress and inflammatory response seem be relevant in both of them. Our objective
was to evaluate oxidative damage and degree of inflammatory infiltrate in aortas of
patients surgically treated for AOD and AAA.
Materials and Methods
Levels of reactive oxygen species (ROS), nicotinamide adenine dinucleotide phosphate
(NADPH) oxidase activity, and myeloperoxidase (MPO) expression as well as nitrite
levels and superoxide dismutase (SOD) and catalase (CAT) activities were evaluated
in aortas of patients with AOD (n = 16) or AAA (n = 14), while the control group was formed by cadaveric organ donors (n = 10). We also analyzed the degree of inflammatory infiltrate in these aortas.
Results
There was an increase in ROS levels and NADPH oxidase activity in patients with AOD
and AAA when compared with the control group, and the AOD group demonstrated higher
ROS production and NADPH oxidase activity and also nitrite levels when compared with
the AAA group (P < 0.001). On the other hand, an increase of SOD activity in the AOD group and CAT
activity in the AAA group was observed. Inflammatory infiltrate and MPO expression
were higher in the AOD group when compared with the control group (P < 0.05).
Conclusions
Oxidative stress is relevant in both AOD and AAA, though AOD presented higher ROS
levels and NADPH activity. Increased activities of antioxidant enzymes may be a compensatory
phenomenon which occurs in aortas of patients with AOD and AAA. Perhaps, a relationship
between oxidative stress and degree of inflammatory infiltrate may exist in the pathophysiology
of AOD and AAA.
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Article info
Publication history
Published online: May 11, 2018
Accepted:
February 23,
2018
Received:
November 10,
2017
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.
