- •Type of research: Single center retrospective review of prospectively maintained ultrasound database data
- •Key Findings: 1581 patients were identified with small abdominal aortic aneurysms (AAA) with a total of 5945 ultrasound studies. Male gender and baseline AAA size of 4.0 –4.9 cm were more likely to demonstrate rapid growth (P = 0.002) and need eventual repair (P <0.001).
- •Take Home Message: The overall low rate of events in small AAAs supports continued surveillance every 3 years for AAAs between 3.0 and 3.9 cm and yearly for male patients with AAAs 4.0 –4.9 cm as recommended by the SVS Guidelines. Female gender may have less rapid growth than previously reported but likely merit more rigorous surveillance, particularly as the AAAs approach 5.0 cm.
- •Table of Contents Summary: SVS guidelines for annual surveillance of AAA 4.0V4.9 cm and every 3 years for AAAs between 3.0 and 3.9 cm is supported by this retrospective review of 1581 patients undergoing ultrasound surveillance.
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
- Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms.Lancet. 1998; 352: 1649-1655
Lederle FA, Johnson GR, Wilson SE, et al. The aneurysm detection and management study screening program: validation cohort and final results. Arch Intern Med 2000;160:1425–1430. Accessed 03/15/2021. Available from: https://jamanetwork.com/.
- The multicentre aneurysm screening study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial.Lancet. 2002; 360: 1531-1539
- Systematic review and meta-analysis of growth rates of small abdominal aortic aneurysms.Br J Surg. 2011; 98: 609-618
Sweeting MJ, Thompson SG, Brown LC, et al. Meta-analysis of individual patient data to examine factors affecting growth and rupture of small abdominal aortic aneurysms. Br J Surg [Internet] 2012;99:655–665. Accessed 03/15/2021. Available from: http://doi.wiley.com/10.1002/bjs.8707.
Thompson S, Brown L, Sweeting M, et al. Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness. Health Technol Assess (Rockv) [Internet] 2013;17:1-93. Accessed 03/13/2021. Available from: https://www.journalslibrary.nihr.ac.uk/hta/hta17410/.
Vega de Céniga M, Gómez R, Estallo L, et al. Growth rate and associated factors in small abdominal aortic aneurysms. Eur J Vasc Endovasc Surg 2006;31:231–236. Accessed 05/15/2021. Available from: https://pubmed.ncbi.nlm.nih.gov/16293428/.
- Metformin treatment status and abdominal aortic aneurysm disease progression.J Vasc Surg. 2016; 64: 46-54
Solberg S, Singh K, Wilsgaard T, et al. Increased growth rate of abdominal aortic aneurysms in women. the tromsø study. Eur J Vasc Endovasc Surg [Internet] 2005;29:145–149. Accessed 05/15/2021. Available from: https://pubmed.ncbi.nlm.nih.gov/15649720/.
Mofidi R, Goldie VJ, Kelman J, et al. Influence of sex on expansion rate of abdominal aortic aneurysms. Br J Surg [Internet] 2007;94:310–314. Accessed 05/15/2021. Available from: https://pubmed.ncbi.nlm.nih.gov/17262754/.
- Gender trends in the repair of ruptured abdominal aortic aneurysms and outcomes.J Vasc Surg. 2010; 51: S9-S14
- The society for vascular surgery practice guidelines on the care of patients with an abdominal aortic aneurysm.J Vasc Surg [Internet]. 2018; 67: 2-77https://doi.org/10.1016/j.jvs.2017.10.044
- metformin prescription associated with reduced abdominal aortic aneurysm growth rate and reduced chemokine expression in a swedish cohort.Ann Vasc Surg. 2021; 70: 425-433
- Metformin prescription status and abdominal aortic aneurysm disease progression in the U.S. veteran population.J Vasc Surg. 2019; 69: 710-716
Fujimura N, Xiong J, Kettler EB, et al. Metformin treatment status and abdominal aortic aneurysm disease progression. J Vasc Surg [Internet] 2016;64:46-54. Accessed 03/15/2021.Available from: https://pubmed.ncbi.nlm.nih.gov/27106243/.
Van De Luijtgaarden KM, Voûte MT, Hoeks SE, et al. Vitamin D deficiency may be an independent risk factor for arterial disease. Eur J Vasc Endovasc Surg [Internet] 2012;44:301–306. Accessed 05/15/2021. Available from: https://pubmed.ncbi.nlm.nih.gov/22841360/.
- Is hypovitaminosis D associated with abdominal aortic aneurysm, and is there a dose-response relationship?.Eur J Vasc Endovasc Surg. 2013; 45: 657-664
Conflict of Interest: The authors declare no conflicts of interest
Funding: This research received no specific grant support from any funding agency in the public, commercial, or not-for-profit sectors.
This study was presented as a plenary presentation at the 2020 Midwestern Vascular Surgical Society 44th Annual Meeting, September 9-12, 2020.