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Role of MMP- 9 in the Etiology of Inguinal Hernia and Vascular Disease A Comment to “Altered Metalloproteinase-9 Expression as Least Common Denominator Between Varicocele, Inguinal Hernia, and Chronic Venous Disorders” by Serra et.all

      The etiology of groin hernias has a strong relationship with the degradation of collagen within the fascia transversalis. So, in 2009,we investigated the roles of matrix metalloproteinases (MMPs) especially, MMP-1, MMP-2, and MMP-9 in the etiology of inguinal hernia.
      • Aren A.
      • Gökçe H.A.
      • Gökçe F.S.
      • et al.
      Roles of matrix metalloproteinases in the etiology of inguinal hernia.
      Our prospective study included 60 inguinal hernia patients: 30 patients had an indirect inguinal hernia and 30 patients had a direct inguinal hernia. An additional 30 patients were operated for reasons other than hernia (varicoceles) in the inguinal canal were also included as a control group. Tissue specimens were taken from the fascia transversalis from patient and control groups during the operation, and MMP-1, MMP-2, MMP-9 values were investigated using immunohistochemical methods. Significantly, higher values of MMP-1, MMP-2, MMP-9, were found in inguinal hernia cases than in the control group (P = 0.0001, P = 0.007, P = 0.021, respectively). Our study was published in 2011 in the Journal of “Hernia”.
      • Aren A.
      • Gökçe H.A.
      • Gökçe F.S.
      • et al.
      Roles of matrix metalloproteinases in the etiology of inguinal hernia.
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