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The efficacy of autologous platelet-rich gel and traditional Chinese medicine in diabetic foot treatment: a parallel randomized controlled clinical trial

  • Liangliang Du
    Affiliations
    Department of Endocrinology, Yueyang Hospital of Traditional Chinese Medicine, No.269 Fengqiao Lake Road, Yueyang City, Hunan Province
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  • Douyun Zeng
    Affiliations
    Department of Endocrinology, Yueyang Hospital of Traditional Chinese Medicine, No.269 Fengqiao Lake Road, Yueyang City, Hunan Province
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  • Xian Hu
    Affiliations
    Department of Endocrinology, Yueyang Hospital of Traditional Chinese Medicine, No.269 Fengqiao Lake Road, Yueyang City, Hunan Province
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  • Xi Ren
    Affiliations
    Department of Endocrinology, Yueyang Hospital of Traditional Chinese Medicine, No.269 Fengqiao Lake Road, Yueyang City, Hunan Province
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  • Dazhi He
    Correspondence
    Corresponding author: Dazhi HE, Department of Endocrinology, Yueyang Hospital of Traditional Chinese Medicine, No.269 Fengqiao Lake Road, Yueyang City, Hunan Province Postal code-414000. Hospital phone number; 07308831711
    Affiliations
    Department of Endocrinology, Yueyang Hospital of Traditional Chinese Medicine, No.269 Fengqiao Lake Road, Yueyang City, Hunan Province
    Search for articles by this author
Published:September 01, 2022DOI:https://doi.org/10.1016/j.avsg.2022.07.026

      Abstract

      Introduction

      Diabetic Foot (DF) is a prevalent metabolic infection. DF wounds are the basis for all cases of non-traumatic lower limbs amputations in diabetes. DF care approaches include debridement of wound, pressure relief in the wounded area, proper wound, infection and ischemia management. However, there is a need for research to develop more effective therapeutic approaches. This study investigated the effectivity and safety of autologous platelet-rich gel combined with conventional treatment and traditional Chinese medicine (TCM) in diabetic foot ulcers therapy.

      Methods

      Sixty diabetic foot ulcer patients were divided into treatment and control groups of 30 patients each. The treatment group involved a combination of autologous platelet-rich gel, conventional treatment, and TCM. The control group was only treated with a combination of conventional therapy and TCM. Laboratory variables, including platelets, hemoglobin, albumin, and HbA1c, were analyzed and compared between treatment and control groups at baseline and end-point. Healing area, volume, and rates were compared in both groups.
      Results: basic patients' data and the wound conditions had no significant difference between treatment and control group. The treatment and control groups cure rates were 93.3% vs. 50%, respectively. The healing rate per two weeks was significantly higher in the treatment than in control group (0.78±0.05 vs. 0.43±0.04). There was no statistically significant difference in the platelets, hemoglobin, albumin, and HbA1c levels in the treatment and control groups.

      Conclusion

      Autologous platelet-rich gel combined with conventional treatment and traditional Chinese medicine (TCM) is effective and safe for diabetic foot ulcers treatment.

      Keywords

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