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Comparison of Complications and Cost for Transfemoral Versus Transcarotid Stenting of Carotid Artery Stenosis

Published:September 19, 2022DOI:https://doi.org/10.1016/j.avsg.2022.08.014

      Abstract

      Background

      Options for endovascular treatment of carotid artery disease have been developed to compliment with carotid endarterectomy, transfemoral carotid artery stenting (TFCAS) and a hybrid approach with transcarotid artery revascularization (TCAR). We sought to capture endpoints outside of stroke, myocardial infarction, and death involved with each procedure at our institution as well as evaluate cost.

      Methods

      Carotid stent procedures performed from 2014 to 2020 at our institution underwent comparative analysis based upon access site and type of stent procedure performed, TFCAS vs TCAR. Procedural details and outcomes were captured prospectively and included in the National Cardiovascular Data Peripheral Vascular Intervention Registry (NCDR-PVI). Further retrospective review was performed to evaluate endpoints beyond stroke, myocardial infarction, and death. Total in-hospital cost, including administrative, capital and utilities (fixed cost) and labor and supplies (variable cost) were also evaluated.

      Results

      137 patients were reviewed. 77 were treated with TFCAS and 60 with TCAR. Mean age was 74 years, predominantly male (68%) and Caucasian (90%), Patients undergoing TFCAS were more likely to be symptomatic compared to those receiving TCAR (81.8% vs. 50.0%, p=<0.001). There were no statistically significant differences in event rates, including mortality, recurrent CVA/TIA, or bleeding. Complications not captured in the NCDR-PVI database were more frequent in the TCAR group (21.7% vs 5.2%, p=0.004) and included pneumothorax (n=2), neck hematoma (n=8), and common carotid artery stenosis or injury (n=3). Rates of complications in the TFCAS group (n=4) were lower and limited to groin hematoma (n=2), central retinal artery occlusion causing vision loss and a case of post-operative dysphagia. Geographic miss of initial stent placement was identified in 15.0% of TCAR patients and 2.6% (p=0.008) of TFCAS patients. Restenosis rates on Duplex ultrasound were similar between the two groups (14.6% of patients) and were not associated with symptoms. The mean follow-up interval was similar for both groups of 31.8 months for TCAR and 30.7 months for TFCAS (p=0.797). There was a statistically significant difference in total cost with TCAR being more expensive ($22,315 vs $11,001) driven by direct costs that included devices, imaging, and extended length of stay in the TCAR group (p <0.001). There was no significant difference between stroke free survival (91.1% vs 88.6%, p=0.69) and mortality (78.1% vs 85.2%, p = 0.677) at 3 years follow up between TCAR and TFCAS respectively.

      Conclusion

      Both TFCAS and TCAR provide similar 3-year stroke and mortality risk/benefit and are distinctly different procedures. Both should be evaluated independently with analysis of variables beyond stroke, death, and myocardial infarction. TFCAS is more cost-effective than TCAR in this single institution study.

      Keywords

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