Background
Transcutaneous oxygen pressure (TcPO2) is a noninvasive, nonradiological test to measure
local oxygen released from capillaries through the skin. Since it reflects the metabolic
state of the lower limb, it can predict wound healing in patients with critical limb
threatening ischemia (CLTI). The purpose of this study was to determine the effectiveness
of TcPO2 test in evaluating wound healing potential of patients with CLTI.
Methods
This was a retrospective, single-center, nonrandomized, and observational study. A
prospectively registered database of patients who visited Vascular Surgery Department
of St. Mary's Hospital for CLTI and underwent TcPO2 tests from October 1, 2015 to
July 1, 2021 was reviewed. Patients were divided into 2 groups: (1) those who had
amputation only; and (2) those who underwent revascularization procedures. Patients
whose wound healing status could not be determined were excluded. The clinical characteristics
of patients, patient characteristics related to lower TcPO2 value, treatment success
rate, and time for the wound to be healed were analyzed.
Results
A total of 84 patients were included in this study. There was no difference in background
patient characteristics between the 2 groups despite better survival within 12 months
and shorter healing time in the revascularization group. A total of 76 patients survived
12 months after surgery, and 63 patients were healed. Higher HbA1c, higher serum creatinine,
history of stroke, and history of coronary artery disease were related to lower TcPO2
value on multiple linear regression. The cutoff value of TcPO2 was determined to be
40 mm Hg for predicting wound healing. This value was similar to those of previous
studies. In addition, there was a negative correlation between TcPO2 and wound healing
time. Correlations among the anklebrachial index (ABI), toe-brachial index (TBI),
and TcPO2 were not determined because ABI and TBI for some patients could not be obtained
due to wound condition.
Conclusions
The TcPO2 value can predict the wound healing process of ischemic lower extremity
injury.
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Article info
Publication history
Published online: December 07, 2022
Accepted:
November 22,
2022
Received:
July 12,
2022
Footnotes
Declaration of Interest: None declared.
Identification
Copyright
© 2022 Published by Elsevier Inc.
