Background
The aim of this study was to demonstrate the biomechanical properties in different
abdominal aortic aneurysm (AAA) presentations of real-life patients. We used the actual
3D geometry of the AAAs under analysis and a realistic, nonlinearly elastic biomechanical
model.
Materials and Methods
Three patients with different clinical scenarios (R: rupture, S: symptomatic, and
A: asymptomatic) with infrarenal aortic aneurysms were studied. Factors affecting
aneurysm behavior such as morphology, wall shear stress (WSS), pressure, and velocities
were studied and analyzed using steady state computer fluid dynamics using SolidWorks
(Dassault Systems SolidWorksCorp., Waltham, Massachusetts).
Results
When analyzing the WSS, Patient R and Patient A had a decrease in the pressure in
the bottom-back region compared with the body of the aneurysm. In contrast, WSS values
appeared to be the most uniform across the entire aneurysm in Patient S. Furthermore,
Patient A had focal small surface regions with high WSS values. The overall WSS in
the unruptured aneurysms (Patient S and Patient A) were a lot higher than in the ruptured
1 (Patient R). All 3 patients showed a pressure gradient, being high at the top and
low at the bottom. All patients had pressure values 20 times smaller in the iliac
arteries compared with the neck of the aneurysm. The overall maximum pressure was
similar between Patient R and Patient A, higher than the maximum pressure of Patient
S.
Conclusions
Computed fluid dynamics was implemented in anatomically accurate models of AAAs in
different clinical scenarios for obtaining a broader understanding of the biomechanical
properties that determine the behavior of AAA. Further analysis and the inclusion
of new metrics and technological tools are needed to accurately determine the key
factors that will compromise the integrity of the patient's aneurysms anatomy.
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References
- Advancements in identifying biomechanical determinants for abdominal aortic aneurysm rupture.Vascular. 2015; 23: 65-77
- Fluid-structure interaction modeling of abdominal aortic aneurysms : the impact of patient-specific inflow conditions and fluid/Solid coupling.J Biomech Eng. 2013; 135: 1-13
- Wall stress distribution on three- dimensionally reconstructed models of human abdominal aortic aneurysm.J Vasc Surg. 2000; 31: 760-769
- 3D modeling of blood flow in simulated abdominal aortic aneurysm.Vasc Endovascular Surg. 2021; 55: 677-683
- CFD modelling of abdominal aortic aneurysm on hemodynamic loads using a realistic geometry with CT.Comput Math Methods Med. 2013; 2013: 1-9
- Reproducibility of deriving parameters of AAA rupture risk from patient-specific 3D finite element models.J Endovasc Ther. 2011; 18: 289-298
- Patient-specific biomechanical profiling in abdominal aortic aneurysm development and rupture.J Vasc Surg. 2010; 52: 480-488
- Meta-analysis of individual patient data to examine factors affecting growth and rupture of small abdominal aortic aneurysms.Br J Surg. 2012; 99: 655-665
- The definition of low wall shear stress and its effect on plaque progression estimation in human coronary arteries.Sci Rep. 2021; 11: 1-11
- Comparison of small symptomatic and asymptomatic abdominal aortic aneurysms based on computational fluid dynamics analysis.Medicine (Baltimore). 2021; 100: e27306
Article info
Publication history
Published online: February 20, 2023
Accepted:
February 4,
2023
Received:
November 1,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Identification
Copyright
© 2023 Elsevier Inc. All rights reserved.
