Abstract
Objective
R2CHA2DS2-VA score has been used to predict short and long-term outcomes in many cardiovascular
diseases. This study aims to validate the R2CHA2DS2-VA score as a long-term major
adverse cardiovascular events (MACE) predictor after CEA. Secondary outcomes were
also assessed regarding the incidence of all-cause mortality, acute myocardial infarction
(AMI), major adverse limb events (MALE), and acute heart failure (AHF).
Methods
From January 2012 to December 2021, patients (n= 205) from a Portuguese tertiary care
and referral center that underwent CEA with regional anesthesia (RA) for carotid stenosis
were selected from a previously collected prospective database, and a post-hoc analysis was performed. Demographics and comorbidities were registered. Clinical
adverse events were assessed 30-days after the procedure and in the subsequent long-term
surveillance period. Statistical analysis was performed by the Kaplan-Meier method
and Cox proportional hazards regression.
Results
Of the patients enrolled, 78.5% were males with a mean age of 70.44 ± 8.9 years. Higher
scores of R2CHA2DS2-VA were associated with long-term MACE (adjusted Hazard Ratio
(aHR) 1.390; 95% Confidence Interval (CI) 1.173-1.647) and mortality (aHR 1.295; 95%
CI 1.08-1.545)
Conclusions
This study demonstrated the potential of the R2CHA2DS2-VA score to predict long-term
outcomes such as AMI, AHF, MACE, and all-cause mortality in a population of patients
submitted to carotid endarterectomy.
KEYWORDS
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Article info
Publication history
Accepted:
February 8,
2023
Received in revised form:
February 6,
2023
Received:
October 19,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Elsevier Inc. All rights reserved.
