HIGHLIGHTS
- •MiRNAs are good candidates as circulating biomarkers (stability in human blood and high sensitivity/ specificity of expression evaluation).
- •Numerous reports have recently demonstrated differential expression of miRNAs in Cardiovascular, Peripheral Arterial and Aneurysmal disease.
- •A total of 25 reports, published from 2012 to 2022, were included in this review (N=1259 patients with AAA, 90% men).
- •The following miRNAs were identified in more than two references: miR-145, miR-24, miR-33, miR-125, let-7, miR-15, miR-191, miR-29 and miR-133.
- •These nine miRNAs are implicated in known pathogenetic mechanisms for AAA.
Abstract
OBJECTIVE
To provide a summary of the current state of research in English medical literature
on circulating miRNAs, as biomarkers for AAA. Additionally, for the most commonly
mentioned circulating miRNAs in the literature, to attempt a documentation of the
biological mechanisms underlying their role in AAA development.
METHODS
A literature search was undertaken in the MEDLINE database. Only reports that involved
peripheral blood samples (whole blood, plasma, serum) were included. The following
terms were used in combination: microrna, mirna, abdominal aortic aneurysm, human,
circulating, plasma, serum, endovascular and EVAR.
RESULTS
A total of 25 reports, published from 2012 to 2022 were included with a total of 1259
patients with AAA, predominantly men (N= 1040, 90%). Six of these reports recruited
healthy donors who underwent ultrasound screening for AAA as control samples. The
majority of studies were undertaken in plasma samples and the most preferred microRNA
profiling method was Real - Time quantitative polymerase chain reaction (qRT-PCR).
The following nine miRNAs (out of a total of 76) were studied in more than two references:
miR-145, miR-24, miR-33, miR-125, let-7, miR-15, miR-191, miR-29 and miR-133.
CONCLUSION
The nine miRNAs described in this study, are implicated in known pathogenetic mechanisms
of AAA such as atherosclerosis, vascular smooth muscle cell phenotype switch and apoptosis,
vascular inflammation, extracellular matrix degradation and lipid metabolism. Identifying
disease-specific miRNAs, in combination with other clinical parameters, as indicators
of AAA, is crucial for early diagnosis as well as follow-up of AAAs. For future research
on miRNAs as AAA biomarkers, strict case and control group definitions, sample acquisition
protocols, and miRNA expression profiling techniques are warranted.
Keywords
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Article info
Publication history
Accepted:
February 23,
2023
Received in revised form:
February 21,
2023
Received:
January 16,
2023
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Elsevier Inc. All rights reserved.
